Using the Oxford cognitive screen to detect cognitive impairment in stroke patients. A comparison with the Mini-Mental State Examination

Background: The Oxford Cognitive Screen (OCS) was recently developed with the aim of describing the cognitive de cits after stroke. The scale consists of 10 tasks encom- passing ve cognitive domains: attention and executive function, language, memory, number processing, and praxis. OCS was devised to be inclusive and un-confounded by aphasia and neglect. As such, it may have a greater potential to be informative on stroke cognitive de cits of widely used instruments, such as the Mini-Mental State Examination (MMSE) or the Montreal Cognitive Assessment, which were originally devised for demented patients. Objective: The present study compared the OCS with the MMSE with regards to their ability to detect cognitive impairments post-stroke. We further aimed to examine perfor- mance on the OCS as a function of subtypes of cerebral infarction and clinical severity. Methods: 325 rst stroke patients were consecutively enrolled in the study over a 9-month period. The OCS and MMSE, as well as the Bamford classi cation and NIHSS, were given according to standard procedures. results: About a third of patients (35.3%) had a performance lower than the cutoff (<22) on the MMSE, whereas 91.6% were impaired in at least one OCS domain, indicating higher incidences of impairment for the OCS. More than 80% of patients showed an impairment in two or more cognitive domains of the OCS. Using the MMSE as a standard of clinical practice, the comparative sensitivity of OCS was 100%. Out of the 208 patients with normal MMSE performance 180 showed impaired performance in at least one domain of the OCS. The discrepancy between OCS and MMSE was particularly strong for patients with milder strokes. As for subtypes of cerebral infarction, fewer patients demonstrated widespread impairments in the OCS in the Posterior Circulation Infarcts category than in the other categories. conclusion: Overall, the results showed a much higher incidence of cognitive impairment with the OCS than with the MMSE and demonstrated no false negatives for OCS vs MMSE. It is concluded that OCS is a sensitive screen tool for cognitive de cits after stroke. In particular, the OCS detects high incidences of stroke-specific cognitive impairments, not detected by the MMSE, demonstrating the importance of cognitive pro ling.Background: The Oxford Cognitive Screen (OCS) was recently developed with the aim of describing the cognitive deficits after stroke. The scale consists of 10 tasks encompassing five cognitive domains: attention and executive function, language, memory, number processing, and praxis. OCS was devised to be inclusive and un-confounded by aphasia and neglect. As such, it may have a greater potential to be informative on stroke cognitive deficits of widely used instruments, such as the Mini-Mental State Examination (MMSE) or the Montreal Cognitive Assessment, which were originally devised for demented patients. Objective: The present study compared the OCS with the MMSE with regards to their ability to detect cognitive impairments post-stroke. We further aimed to examine performance on the OCS as a function of subtypes of cerebral infarction and clinical severity. Methods: 325 first stroke patients were consecutively enrolled in the study over a 9-month period. The OCS and MMSE, as well as the Bamford classification and NIHSS, were given according to standard procedures. Results: About a third of patients (35.3%) had a performance lower than the cutoff(< 22) on the MMSE, whereas 91.6% were impaired in at least one OCS domain, indicating higher incidences of impairment for the OCS. More than 80% of patients showed an impairment in two or more cognitive domains of the OCS. Using the MMSE as a standard of clinical practice, the comparative sensitivity of OCS was 100%. Out of the 208 patients with normal MMSE performance 180 showed impaired performance in at least one domain of the OCS. The discrepancy between OCS and MMSE was particularly strong for patients with milder strokes. As for subtypes of cerebral infarction, fewer patients demonstrated widespread impairments in the OCS in the Posterior Circulation Infarcts category than in the other categories. Conclusion: Overall, the results showed a much higher incidence of cognitive impairment with the OCS than with the MMSE and demonstrated no false negatives for OCS vs MMSE. It is concluded that OCS is a sensitive screen tool for cognitive deficits after stroke. In particular, the OCS detects high incidences of stroke-specific cognitive impairments, not detected by the MMSE, demonstrating the importance of cognitive profiling. © 2018 Mancuso, Demeyere, Abbruzzese, Damora, Varalta, Pirrotta, Antonucci, Matano, Caputo, Caruso, Pontiggia, Coccia, Ciancarelli, Zoccolotti and The Italian OCS Grou

Validation of PARADISE 24 and Development of PARADISE-EDEN 36 in Patients with Dementia

Dementia was one of the conditions focused on in an EU (European Union) project called “PARADISE” (Psychosocial fActors Relevant to brAin DISorders in Europe) that later produced a measure called PARADISE 24, developed within the biopsychosocial model proposed in the International Classification of Functioning Disability and Health (ICF). The aims of this study are to validate PARADISE 24 on a wider sample of patients with mild to moderate dementia to expand PARADISE 24 by defining a more specific scale for dementia, by adding 18 questions specifically selected for dementia, which eventually should be reduced to 12. We enrolled 123 persons with dementia, recruited between July 2017 and July 2019 in home care and long-term care facilities, in Italy, and 80 participants were recruited in Warsaw between January and July 2012 as part of a previous cross-sectional study. The interviews with the patient and/or family were conducted by health professionals alone or as a team by using the Paradise data collection protocol. The psychometric analysis with the Rasch analysis has shown that PARADISE 24 and the selection of 18 additional condition-specific items can be expected to have good measurement properties to assess the functional state in persons with dementia

Using the Oxford Cognitive Screen to detect cognitive impairment in stroke patients: a comparison with the Mini-Mental State Examination

Background: The Oxford Cognitive Screen (OCS) was recently developed with the aim of describing the cognitive deficits after stroke. The scale consists of 10 tasks encompassing five cognitive domains: attention and executive function, language, memory, number processing, and praxis. OCS was devised to be inclusive and un-confounded by aphasia and neglect. As such, it may have a greater potential to be informative on stroke cognitive deficits of widely used instruments, such as the Mini-Mental State Examination (MMSE) or the Montreal Cognitive Assessment, which were originally devised for demented patients. Objective: The present study compared the OCS with the MMSE with regards to their ability to detect cognitive impairments post-stroke. We further aimed to examine performance on the OCS as a function of subtypes of cerebral infarction and clinical severity. Methods: 325 first stroke patients were consecutively enrolled in the study over a 9-month period. The OCS and MMSE, as well as the Bamford classification and NIHSS, were given according to standard procedures. Results: About a third of patients (35.3%) had a performance lower than the cutoff (<22) on the MMSE, whereas 91.6% were impaired in at least one OCS domain, indicating higher incidences of impairment for the OCS. More than 80% of patients showed an impairment in two or more cognitive domains of the OCS. Using the MMSE as a standard of clinical practice, the comparative sensitivity of OCS was 100%. Out of the 208 patients with normal MMSE performance 180 showed impaired performance in at least one domain of the OCS. The discrepancy between OCS and MMSE was particularly strong for patients with milder strokes. As for subtypes of cerebral infarction, fewer patients demonstrated widespread impairments in the OCS in the Posterior Circulation Infarcts category than in the other categories. Conclusion: Overall, the results showed a much higher incidence of cognitive impairment with the OCS than with the MMSE and demonstrated no false negatives for OCS vs MMSE. It is concluded that OCS is a sensitive screen tool for cognitive deficits after stroke. In particular, the OCS detects high incidences of stroke-specific cognitive impairments, not detected by the MMSE, demonstrating the importance of cognitive profiling

A university Nano satellite for student international cooperation through hands-on education

IKUNS (Italian Kenyan University Nano Satellite) is a student project developed in the framework of the ASI (Agenzia Spaziale Italiana) - "La Sapienza - University of Rome" agreement for the management and activity at the Broglio Space Centre (BSC), in particular mainly involving S5LAB (Sapienza Space System and Space Surveillance Laboratory) of La Sapienza and University of Nairobi. The project goal is the design, development, testing and operation of a 6U Cubesat for Earth observation in visual band, partially based on the use of COTS (Commercial Off The Shelf) devices, trading off between minimum cost and reliability. The feasibility study of this satellite was conducted as a part of the Spacecraft Design course, taught in the Space and Astronautical Engineering MSc Course, at Faculty Sapienza University of Rome. The course provides the basis for the design of a spacecraft, including integrated design methodologies and international standard. All the phases of spacecraft design were analyzed, from mission conceptual design to the spacecraft architecture definition and subsystems preliminary design, realization procedures, up to ground testing and qualification for launch. One of the major students opportunities offered by this project is the possibility to work in ASI Concurrent Engineering Facility (CEF). This facility provides an environment and tools to support a group of experts in different disciplines to exploit a space mission feasibility study (Phase 0 and Phase A) within few weeks. Each student team composed by two or three students managed a different disciplines: System, Mission analysis, Payload, Attitude Determination and Control System, On Board Data Handling, Configuration and Structure, Telemetry Tracking and Command, Ground Segment, Power, Thermal, Costs, Risks and Programming. The first sessions were used for the identification of the spacecraft requirements, while the subsequent dimensioning was performed by iterative process, until a convergence to a preliminary configuration. The paper describes the project and the achieved results, thanks to the concurrent engineering approach integrated in a university course, that guarantees an innovative method: students can acquire an overview of the entire satellite and comprehend how a real project works, increasing their cooperative skills, learning from each other

IKUNS: Italian Kenyan University Nano Satellite

IKUNS (Italian Kenyan University Nano Satellite) is a project arose in the frame of the ASI (Italian Space Agency) - "Sapienza, University of Rome" agreement for the management and operations of Broglio Space Centre (BSC) in Malindi, Kenya. The project entails the collaboration between Italian and Kenyan universities, promoting the development of a Kenyan space program. IKUNS is a 6U CubeSat whose preliminary design has been carried out by M.Sc. Space and Astronautical Engineering students of Sapienza University, through a Concurrent Engineering preliminary study, exploited at the ASI CEF Facility during fall 2015. The bus will be mainly designed and manufactured at the Sapienza University S5Lab (Sapienza Space System and Space Surveillance Laboratory), while primary payload is expected to be provided by Kenyan partners, which will also be involved in system integration and testing activities. This collaboration allows students, from both parties, to gain valuable expertise on space mission design, from the preliminary design to the data analysis. In this regard, several subsystems will be in-house developed by the S5Lab, while the main ground station, located at the Broglio Space Centre, will give students from the University of Nairobi, the opportunity to be involved in operations and data analysis during the life-time of the satellite. Throughout the progress of the mission, not only the technical knowhow, but also the students' capability of working in an international environment will be enhanced. The tight collaboration required, typical of space missions development, make the need for a well-defined and continuous communication link between all parties involved, to guarantee an effective information exchange during the entire project. Additionally, seen the increasing interest in low cost Nano Satellites, the IKUNS mission paves the way for future up-to-date projects, by the application of similar collaboration frame. The paper describes the requirements and methodology adopted in the preliminary design of IKUNS, highlighting the international collaborative aspect of the project, and providing an outlook on future operations and possibilities

Using the Oxford Cognitive Screen to Detect Cognitive Impairment in Stroke Patients: A Comparison with the Mini-Mental State Examination

BackgroundThe Oxford Cognitive Screen (OCS) was recently developed with the aim of describing the cognitive deficits after stroke. The scale consists of 10 tasks encompassing five cognitive domains: attention and executive function, language, memory, number processing, and praxis. OCS was devised to be inclusive and un-confounded by aphasia and neglect. As such, it may have a greater potential to be informative on stroke cognitive deficits of widely used instruments, such as the Mini-Mental State Examination (MMSE) or the Montreal Cognitive Assessment, which were originally devised for demented patients.ObjectiveThe present study compared the OCS with the MMSE with regards to their ability to detect cognitive impairments post-stroke. We further aimed to examine performance on the OCS as a function of subtypes of cerebral infarction and clinical severity.Methods325 first stroke patients were consecutively enrolled in the study over a 9-month period. The OCS and MMSE, as well as the Bamford classification and NIHSS, were given according to standard procedures.ResultsAbout a third of patients (35.3%) had a performance lower than the cutoff (&lt;22) on the MMSE, whereas 91.6% were impaired in at least one OCS domain, indicating higher incidences of impairment for the OCS. More than 80% of patients showed an impairment in two or more cognitive domains of the OCS. Using the MMSE as a standard of clinical practice, the comparative sensitivity of OCS was 100%. Out of the 208 patients with normal MMSE performance 180 showed impaired performance in at least one domain of the OCS. The discrepancy between OCS and MMSE was particularly strong for patients with milder strokes. As for subtypes of cerebral infarction, fewer patients demonstrated widespread impairments in the OCS in the Posterior Circulation Infarcts category than in the other categories.ConclusionOverall, the results showed a much higher incidence of cognitive impairment with the OCS than with the MMSE and demonstrated no false negatives for OCS vs MMSE. It is concluded that OCS is a sensitive screen tool for cognitive deficits after stroke. In particular, the OCS detects high incidences of stroke-specific cognitive impairments, not detected by the MMSE, demonstrating the importance of cognitive profiling

Momentum Transfer from the DART Mission Kinetic Impact on Asteroid Dimorphos.

The NASA Double Asteroid Redirection Test (DART) mission performed a kinetic impact on asteroid Dimorphos, the satellite of the binary asteroid (65803) Didymos, at 23:14 UTC on September 26, 2022 as a planetary defense test1. DART was the first hypervelocity impact experiment on an asteroid at size and velocity scales relevant to planetary defense, intended to validate kinetic impact as a means of asteroid deflection. Here we report the first determination of the momentum transferred to an asteroid by kinetic impact. Based on the change in the binary orbit period2, we find an instantaneous reduction in Dimorphos's along-track orbital velocity component of 2.70 ± 0.10 mm s-1, indicating enhanced momentum transfer due to recoil from ejecta streams produced by the impact3,4. For a Dimorphos bulk density range of 1,500 to 3,300 kg m-3, we find that the expected value of the momentum enhancement factor, [Formula: see text], ranges between 2.2 and 4.9, depending on the mass of Dimorphos. If Dimorphos and Didymos are assumed to have equal densities of 2,400 kg m-3, [Formula: see text]. These [Formula: see text] values indicate that significantly more momentum was transferred to Dimorphos from the escaping impact ejecta than was incident with DART. Therefore, the DART kinetic impact was highly effective in deflecting the asteroid Dimorphos

The HERMES-technologic and scientific pathfinder

HERMES-TP/SP (High Energy Rapid Modular Ensemble of Satellites Technologic and Scientific Pathfinder) is a constellation of six 3U nano-satellites hosting simple but innovative X-ray detectors, characterized by a large energy band and excellent temporal resolution, and thus optimized for the monitoring of Cosmic High Energy transients such as Gamma Ray Bursts and the electromagnetic counterparts of Gravitational Wave Events, and for the determination of their positions. The projects are funded by the Italian Ministry of University and Research and by the Italian Space Agency, and by the European Union's Horizon 2020 Research and Innovation Program under Grant Agreement No. 821896. HERMES-TP/SP is an in-orbit demonstration, that should be tested starting from 2022. It is intrinsically a modular experiment that can be naturally expanded to provide a global, sensitive all sky monitor for high-energy transients

The scientific payload on-board the HERMES-TP and HERMES-SP CubeSat missions

none103siHERMES (High Energy Rapid Modular Ensemble of Satellites) Technological and Scientific pathfinder is a space borne mission based on a LEO constellation of nano-satellites. The 3U CubeSat buses host new miniaturized detectors to probe the temporal emission of bright high-energy transients such as Gamma-Ray Bursts (GRBs). Fast transient localization, in a field of view of several steradians and with arcmin-level accuracy, is gained by comparing time delays among the same event detection epochs occurred on at least 3 nano-satellites. With a launch date in 2022, HERMES transient monitoring represents a keystone capability to complement the next generation of gravitational wave experiments. In this paper we will illustrate the HERMES payload design, highlighting the technical solutions adopted to allow a wide-energy-band and sensitive X-ray and gamma-ray detector to be accommodated in a CubeSat 1U volume together with its complete control electronics and data handling system.noneEvangelista, Yuri; Fiore, Fabrizio; Fuschino, Fabio; Campana, Riccardo; Ceraudo, Francesco; Demenev, Evgeny; Guzman, Alejandro; Labanti, Claudio; La Rosa, Giovanni; Fiorini, Mauro; Gandola, Massimo; Grassi, Marco; Mele, Filippo; Morgante, Gianluca; Nogara, Paolo; Piazzolla, Raffaele; Pliego Caballero, Samuel; Rashevskaya, Irina; Russo, Francesco; Sciarrone, Giulia; Sottile, Giuseppe; Milankovich, Dorottya; Pál, András; Ambrosino, Filippo; Auricchio, Natalia; Barbera, Marco; Bellutti, Pierluigi; Bertuccio, Giuseppe; Borghi, Giacomo; Cao, Jiewei; Chen, Tianxiang; Dilillo, Giuseppe; Feroci, Marco; Ficorella, Francesco; Lo Cicero, Ugo; Malcovati, Piero; Morbidini, Alfredo; Pauletta, Giovanni; Picciotto, Antonino; Rachevski, Alexandre; Santangelo, Andrea; Tenzer, Chistoph; Vacchi, Andrea; Wang, Lingjun; Xu, Yupeng; Zampa, Gianluigi; Zampa, Nicola; Zorzi, Nicola; Burderi, Luciano; Lavagna, Michèle; Bertacin, Roberto; Lunghi, Paolo; Monge, Angel; Negri, Barbara; Pirrotta, Simone; Puccetti, Simonetta; Sanna, Andrea; Amarilli, Fabrizio; Amelino-Camelia, Giovanni; Bechini, Michele; Citossi, Marco; Colagrossi, Andrea; Curzel, Serena; Della Casa, Giovanni; Cinelli, Marco; Del Santo, Melania; Di Salvo, Tiziana; Feruglio, Chiara; Ferrandi, Fabrizio; Fiorito, Michele; Gacnik, Dejan; Galgóczi, Gabor; Gambino, Angelo Francesco; Ghirlanda, Giancarlo; Gomboc, Andreja; Karlica, Mile; Efremov, Pavel; Kostic, Uros; Clerici, Aurora; Lopez Fernandez, Borja; Maselli, Alessandro; Nava, Lara; Ohno, Masanori; Ottolina, Daniele; Pasquale, Andrea; Perri, Matteo; Piccinin, Margherita; Prinetto, Jacopo; Riggio, Alessandro; Ripa, Jakub; Papitto, Alessandro; Piranomonte, Silvia; Scala, Francesca; Selcan, David; Silvestrini, Stefano; Rotovnik, Tomaz; Virgilli, Enrico; Troisi, Ivan; Werner, Norbert; Zanotti, Giovanni; Anitra, Alessio; Manca, Arianna; Clerici, AuroraEvangelista, Yuri; Fiore, Fabrizio; Fuschino, Fabio; Campana, Riccardo; Ceraudo, Francesco; Demenev, Evgeny; Guzman, Alejandro; Labanti, Claudio; La Rosa, Giovanni; Fiorini, Mauro; Gandola, Massimo; Grassi, Marco; Mele, Filippo; Morgante, Gianluca; Nogara, Paolo; Piazzolla, Raffaele; Pliego Caballero, Samuel; Rashevskaya, Irina; Russo, Francesco; Sciarrone, Giulia; Sottile, Giuseppe; Milankovich, Dorottya; Pál, András; Ambrosino, Filippo; Auricchio, Natalia; Barbera, Marco; Bellutti, Pierluigi; Bertuccio, Giuseppe; Borghi, Giacomo; Cao, Jiewei; Chen, Tianxiang; Dilillo, Giuseppe; Feroci, Marco; Ficorella, Francesco; Lo Cicero, Ugo; Malcovati, Piero; Morbidini, Alfredo; Pauletta, Giovanni; Picciotto, Antonino; Rachevski, Alexandre; Santangelo, Andrea; Tenzer, Chistoph; Vacchi, Andrea; Wang, Lingjun; Xu, Yupeng; Zampa, Gianluigi; Zampa, Nicola; Zorzi, Nicola; Burderi, Luciano; Lavagna, Michèle; Bertacin, Roberto; Lunghi, Paolo; Monge, Angel; Negri, Barbara; Pirrotta, Simone; Puccetti, Simonetta; Sanna, Andrea; Amarilli, Fabrizio; Amelino-Camelia, Giovanni; Bechini, Michele; Citossi, Marco; Colagrossi, Andrea; Curzel, Serena; Della Casa, Giovanni; Cinelli, Marco; Del Santo, Melania; Di Salvo, Tiziana; Feruglio, Chiara; Ferrandi, Fabrizio; Fiorito, Michele; Gacnik, Dejan; Galgóczi, Gabor; Gambino, Angelo Francesco; Ghirlanda, Giancarlo; Gomboc, Andreja; Karlica, Mile; Efremov, Pavel; Kostic, Uros; Clerici, Aurora; Lopez Fernandez, Borja; Maselli, Alessandro; Nava, Lara; Ohno, Masanori; Ottolina, Daniele; Pasquale, Andrea; Perri, Matteo; Piccinin, Margherita; Prinetto, Jacopo; Riggio, Alessandro; Ripa, Jakub; Papitto, Alessandro; Piranomonte, Silvia; Scala, Francesca; Selcan, David; Silvestrini, Stefano; Rotovnik, Tomaz; Virgilli, Enrico; Troisi, Ivan; Werner, Norbert; Zanotti, Giovanni; Anitra, Alessio; Manca, Arianna; Clerici, Auror